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Thomas was born in Hollywood, California. A precocious talent, he was thrust into fame at the age of 25 when as an assistant he took over a concert of the Boston Symphony from an ailing William Steinberg in 1969. He subsequently became principal guest conductor for the orchestra 196974. He went on to guest-conduct widely and led the Buffalo Philharmonic Orchestra 197179 and the London Symphony Orchestra in 1988. He has won several Grammy Awards for both his performances and his albums.