valve (biology)

In animals, a structure for controlling the direction of the blood flow. In humans and other vertebrates, the contractions of the beating heart cause the correct blood flow into the arteries because a series of valves prevents back flow. Diseased valves, detected as ‘heart murmurs’, have decreased efficiency. The tendency for low-pressure venous blood to collect at the base of limbs under the influence of gravity is counteracted by a series of small valves within the veins. It was the existence of these valves that prompted the 17th-century physician William Harvey to suggest that the blood circulated around the body.