chromosome

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Structures in a cell nucleus that carry the many thousands of genes, in sequence, that determine the characteristics of an organism. There are 46 chromosomes in a normal human cell. Each chromosome normally consists of one very long strand (or molecule) of DNA, coiled and folded to produce a compact structure. The exception is just before cell division when each chromosome contains two strands of DNA, a result of the copying of each molecule of DNA. The point on a chromosome where a particular gene occurs is known as its locus. Most higher organisms have two copies of each chromosome, together known as a homologous pair (they are diploid) but some have only one (they are haploid). See also mitosis and meiosis.

In a working cell chromosomes exist in a less dense form called chromatin and cannot be seen using a laboratory light microscope. However, during cell division they get shorter and fatter and so become visible. When pictures are seen of chromosomes, they have usually been taken in this state during mitosis. In such pictures of human chromosomes it can be seen that most chromosomes in a cell have a matching chromosome of exactly the same size. These are known as homologous pairs. However, one pair is not matched. These are the sex chromosomes – a short, male determining one called the Y chromosome and the X chromosome. Males have an X and a Y chromosome and females have two Xs.

In a sex cell (gamete) that has been produced by meiosis, the number of chromosomes is halved. Only one chromosome from each pair of homologous chromosomes is found in a gamete.

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