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He met Matisse at the Ecole des Beaux-Arts and exhibited with him and the Fauves 1905, though he had more affinity with the German expressionists than with his French contemporaries. His works convey both an acute awareness of suffering in the world and a deep religious belief: compassion in his depictions of clowns and prostitutes gives way to harsh social comment in his pictures of lawyers and judges, as in Les Noces (Tate Gallery, London). His sombre view of the human condition is conveyed by sombre tones and distortions of form, though as time went on he gave his religious themes something of the dusky richness of stained glass.
He illustrated books for the art dealer Ambroise Vollard, for whom all his productions were reserved for many years. The etched plates for Miserere 1948 (executed 192227) represent a major achievement in 20th-century graphic art.