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Gangrene sets in as a result of loss of blood supply to the area. This may be due to disease (diabetes, atherosclerosis), an obstruction of a major blood vessel (as in thrombosis), injury, or frostbite. Bacteria colonize the site unopposed, and a strong risk of blood poisoning often leads to surgical removal of the tissue or the affected part (amputation).
The white saltire comes from the flag of Scotland. The St Patrick's Cross was, in fact, taken from the arms of the powerful Geraldine family. The red cross of St George is taken from the flag of England. Effective date: 1 January 1801.
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