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"There are worries about the health of the U.S. economy ... that will persist even if the credit crunch issues ease slightly," said Jane Strawbridge, senior research analyst at Christows Stockbrokers in Exeter.
"I don't think the outlook for the UK consumer will improve any time soon either."
In more grim news for the UK economy, Britain's services sector contracted in September at its fastest rate since records began 12 years ago according to data from the Chartered Institute of Purchasing and Supply/Markit.
Financial stocks were under pressure with sentiment still overshadowed by continued strains in the money markets, with interbank rates remaining high.
Interdealer broker ICAP
However. recent heavily sold banks gained with HBOS
Barclays
Life assurer Old Mutual
DARKENING OUTLOOK
Equity investors were nervous as a darkening economic outlook and continuing uncertainty about the fate of a $700 billion (395 billion pound) bailout for the U.S. financial industry has kept the UK blue-chip index close to its lowest level in over three years.
The UK benchmark is down 4.2 percent this week and 25 percent this year.
"There are plenty of reasons for people not to have bets on the table ahead of the weekend," said Jeremy Batstone-Carr, head of private client research at Charles Stanley.
"The markets are going to be treacherous, we are close to two big hurdles, the last of which (the vote on the bailout) is after markets in Europe close... so it will take a tenacious investor to make an investment on a day like today."
Mining stocks fell with gold hit by a rising dollar and platinum near its weakest in almost three years on demand fears, while base metals like zinc and copper were also lower.
Lonmin
British Airways
Shares in Imperial Tobacco
Shares in Autonomy Corporation
(Editing by Greg Mahlich)