Nexavar (sorafenib)

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The following medicines could theoretically decrease the absorption of sorafenib from the gut and so could make it less effective. This has not been studied, so the these medicines should be avoided where possible while you are taking sorafenib:

- antacids for indigestion or heartburn
- H2 antagonists, eg cimetidine, ranitidine, famotidine
- proton pump inhibitors, eg omeprazole, lansoprazole.

The following medicines may increase the breakdown of sorafenib by the body and so could decrease the amount of sorafenib in the blood:

- barbiturates, eg phenobarbital, amobarbital
- carbamazepine
- dexamethasone
- phenytoin
- rifampicin
- the herbal remedy St John's wort (Hypericum perforatum).

As these medicines could make sorafenib less effective they should be avoided where possible while you are taking this medicine.

Sorafenib may increase the anti-blood-clotting effect of anticoagulant medicines such as warfarin. If you are taking an anticoagulant in combination with sorafenib, your blood clotting time (INR) should be monitored more frequently.

Sorafenib may increase the blood level of the chemotherapy medicines irinotecan, doxorubicin and docetaxel.

Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain sorafenib as the active ingredient.

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