Tramacet

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Dry mouth

Changes in mood

Confusion

Sweating

Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain

Abnormal heart beats (arrhythmias)

Seizures (convulsions)

False perceptions of things that are not really there (hallucinations)

Pins and needles (paraesthesia)

Awareness of your heartbeat (palpitations)

Dizziness

Difficulty in breathing (dyspnoea)

Sleepiness (somnolence)

Difficulty or pain on passing urine (dysuria)

Skin reactions such as rash and itch

Anxiety

Difficulty or pain when swallowing (dysphagia)

Trembling

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

You should tell your doctor or pharmacist what medicines you are using, particularly those listed below, before you start treatment with this medicine. This includes those bought without a prescription and herbal medicines. Likewise, check with your doctor or pharmacist before starting any new medicines while you are taking this medicine. The manufacturer states that this medicine should not be taken at the same time as, or within two weeks of, monoamine oxidase inhibitors (MAOIs). These include the following medicines: - MAOI antidepressants such as phenelzine, tranylcypromine, isocarboxacid, - the MAO-A inhibitor antidepressant moclobemide - the MAO-B inhibitor selegiline, used for Parkinson's disease - the antibiotic linezolid. There is an increased risk of drowsiness and sedation if this medicine is taken with other medicines that can cause drowsiness, such as the following: - tricyclic antidepressants, eg amitriptyline - some antipsychotics - other opioids, eg codeine, morphine - benzodiazepines, eg diazepam - barbiturates, eg phenobarbital - sedating antihistamines, eg chlorpheniramine - sleeping tablets. There may be an increased risk of convulsions or seizures if this medicine is taken with SSRI antidepressants (eg fluoxetine), tricyclic antidepressants (eg amitriptyline), antipsychotics (eg chlorpromazine) or bupropion. If this medicine is taken with SSRI antidepressants such as fluoxetine, or triptans for migraine such as sumatripitan, there may also be an increased risk of other side effects, as these medicines all enhance the activity of serotonin in the brain. The manufacturer states that this medicine is not recommended for use in combination with the following medicines: buprenorphine, nalbuphine, pentazocine. Carbamazepine may decrease the blood level of tramadol, which may make it less effective at relieving pain. Tramadol and regular or long-term use of paracetamol may enhance the anti-blood-clotting effect of anticoagulant medicines such as warfarin. If you are taking warfarin your blood clotting time (INR) should be monitored when you start and stop treatment with this medicine. You should avoid taking other medicines that contain paracetamol or tramadol while taking this medicine, as this can easily result in exceeding the maximum recommended daily dose of these medicines. Many cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of any other medicines before taking them with this one. Cholestyramine may reduce the absorption of paracetamol from the gut. Metoclopramide and domperidone may increase the absorption of paracetamol from the gut.

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