Riamet (artemether, lumefantrine)

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache.

Dizziness.

Loss of appetite.

Disturbances of the gut such as nausea, vomiting, diarrhoea or abdominal pain.

Fatigue.

Weakness or loss of strength (asthenia).

Cough.

Pain in the muscles and joints.

Pins and needles or numb sensations.

Rash or itching.

Awareness of your heartbeat (palpitations).

Abnormal heart rhythm.

Sleepiness.

Involuntary muscle contractions.

Shaky movements and unsteady walk (ataxia).

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The manufacturer states that this medicine should not be taken in combination with any other antimalarial medicine, due to limited data on the safety and efficacy of combination treatment.

The manufacturer states that this medicine must not be taken in combination with the following medicines, because it may increase the amount of these medicines in the blood and increase the chance of their side effects:

amitriptyline

clomipramine

imipramine

flecainide

metoprolol.

The manufacturer states that this medicine must not be taken with any of the following medicines, because the combination may increase the risk of abnormal heart rhythms:

certain medicines for irregular heart rhythms (antiarrhythmics), eg mexiletine, propafenone, procainamide, disopyramide, amiodarone, quinidine, sotalol

antidepressant medicines, eg amitriptyline, maprotiline, fluoxetine

antipsychotic medicines, eg chlorpromazine, thioridazine, haloperidol

other antimalarials, eg quinine, halofantrine (patients previously treated with halofantrine should not receive this medicine until at least one month after their last halofantrine dose)

the antihistamines astemizole or terfenadine

cisapride

certain anti-infectives, eg erythromycin, clarithromycin, ketoconazole, moxifloxacin, pentamidine, voriconazole.

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