How does it work?

This medicine contains the active ingredient ketotifen, which is a type of medicine called an antihistamine. It works by preventing the actions of histamine. Histamine is a substance produced by the body as part of its defence mechanisms. It is stored in cells called mast cells, in almost all tissues of the body. When the body reacts to a foreign substance (known as an allergen, eg flower pollen), the mast cells stimulated by the allergen release their stores of histamine. The released histamine then binds to its receptors (H-1 receptors), causing a chain reaction that results in allergic symptoms. It causes an increase in blood flow to the area of the allergy, and the release of other chemicals that add to the allergic response. All this results in the symptoms of an allergic reaction. In eye allergies, such as seasonal allergic conjunctivitis, histamine causes inflammation of the eyes, making them red, itchy and watery. Ketotifen eye drops work by blocking the histamine receptors in the eye. Ketotifen does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This stops it causing inflammation and thus provides relief from the symptoms of the eye allergy.

What is it used for?

Seasonal allergic conjunctivitis

Warning!

This medicine is not to be taken by mouth.

This medicine should discarded four weeks after opening. You may find it helpful to write the date of opening on the pack. Dispose of carefully.

This medicine may cause drowsiness and blurred vision. If affected do not drive or operate machinary.

If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments last.

These eye drops contain the preservative benzalkonium chloride, which can be absorbed by soft contact lenses. If you wear soft contact lenses, you should remove them before putting in these eye drops. You can put the contact lenses back in 15 minutes after using the drops.

When using the eye drops you should take care to not touch the dropper tip to any surface, or to your eye, in order to avoid contaminating the eye drops.

Not to be used in

Children under three years of age

Known sensitivity or allergy to any ingredient

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The safety of this medicine in pregnancy has not been established. It should therefore be used with caution during pregnancy, and only if the benefits to the mother outweigh any risks to the foetus. Seek medical advice from your doctor.

This medicine is unlikely to be excreted into the breast milk after application to the eye, and this medicine may therefore be used by breastfeeding mothers. For further advice talk to your doctor or pharmacist.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Dry mouth

Skin rashes

Allergic reaction to active ingredient

Dislike of light (photophobia)

Inflammation of the lining of the eye, causing pain and redness (conjunctivitis)

Sleepiness (somnolence)

Dry eyes

Pain in the eye

Blurred vision after application

Eye burning/stinging

Tiny breaks on the skin covering the eye (punctate corneal epithelial erosion)

Eyelid disorder

Bleeding under the surface of the eye (subconjunctival haemorrhage)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop from washing away the first. Use any eye gels or ointments last. Eye drops can be absorbed into the bloodstream from the eye, and once in the bloodstream they have the potential to interact with other medicines. For this reason you should be aware of that ketotifen may potentially enhance the sedative effects of the following: - alcohol - tricyclic antidepressants, eg amitriptyline - narcotics, eg morphine, codeine - benzodiazepines, eg diazepam - sedating antihistamines, eg chlorpheniramine - sleeping tablets. Tell your doctor or pharmacist if you are taking any other medicines, including over-the-counter and herbal medicines, before you start treatment with this medicine.

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