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This medicine should not be used by people who are currently taking a monoamine oxidase inhibitor antidepressant, eg phenelzine, tranylcypromine, isocarboxazid or moclobemide, or who have taken one of these medicines in the last 14 days. This is because the combination of pseudoephedrine with these medicines could cause a dangerous increase in blood pressure.
Ibuprofen should not be taken in combination with painkilling doses of aspirin or any other oral NSAID, as this increases the risk of side effects on the stomach and intestines. People taking selective inhibitors of COX-2 such as celecoxib or etoricoxib should avoid this medicine for the same reason.
There may be an increased risk of ulceration or bleeding from the gut if ibuprofen is taken with corticosteroids such as prednisolone.
There may also be an increased risk of bleeding from the gut if ibuprofen is taken with the following medicines:
- anti-blood-clotting (anticoagulant) medicines such as warfarin
- antiplatelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, dipydridamole, clopidogrel
- SSRI antidepressants, eg fluoxetine, paroxetine, citalopram
- venlafaxine.
There may be an increased risk of side effects on the kidneys if ibuprofen is taken in combination with any of the following medicines:
- ACE inhibitors, eg enalapril
- ciclosporin
- diuretics, eg furosemide
- tacrolimus.
Ibuprofen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines:
- digoxin
- lithium
- methotrexate.
Ibuprofen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:
- amlodipine
- ACE inhibitors such as captopril
- beta-blockers.
Pseudoephedrine may also reduce the effects of medicines to treat high blood pressure (antihypertensives). If you are taking medicines for high blood pressure you should not take this medicine.
If pseudoephedrine is taken with any of the following, the combination may cause an increase in blood pressure. If you are already taking any of these medicines you should avoid taking this one as well:
- other decongestants (often found in other non-prescription cough and cold remedies)
- tricyclic antidepressants, eg amitriptyline
- appetite suppressants
- amphetamine-like stimulants.
Other medicines containing the same active ingredients
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