How can this medicine affect other medicines?

This medicine must not be taken at the same time as, or within two weeks of, any of the following: - monoamine oxidase inhibitor antidepressants (MAOIs) - medicines acting on the brain for the treatment of psychiatric disorders, eg antidepressants, antipsychotics - medicines acting on the brain to aid weight loss - tryptophan to aid sleep. Sibutramine should also not be used at the same time as other medicines that increase serotonin levels in the brain, as this may result in a serious side effect called the serotonin syndrome. These medicines include: - some antimigraine medicines, eg sumatriptan, dihydroergotamine - some opioid painkillers, eg pentazocine, fentanyl, pethidine, dextromethorphan. The following medicines may increase the blood level of sibutramine, which may increase the risk of side effects: - ketoconazole, itraconazole (antifungals) - erythromycin, clarithromycin (antibiotics) - ciclosporin. The following medicines may decrease the blood level of sibutramine, making it less effective: - antiepileptics, eg phenobarbitone, phenytoin, carbamazepine - rifampicin - dexamethasone. Consult your doctor or pharmacist before taking cough, cold and allergy medicines with sibutramine. This is because the ingredients of some of these medicines, eg pseudoephedrine, ephedrine, xylometazoline, can also increase blood pressure and heart rate, and should be used with caution with sibutramine. Tell your doctor or pharmacist if you are taking any medicines before you start sibutramine, and also consult them before taking any new medicines during treatment.

Other medicines containing the same active ingredients

Reductil

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