Trizivir

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Rifampicin may decrease the blood level of zidovudine and therefore reduce its effectiveness.

The following medicines may increase the blood level of zidovudine and may therefore increase the risk of its side effects:

- probenecid
- atovaquone
- sodium valproate
- fluconazole
- methadone
- benzodiazepines, eg oxazepam, lorazepam.

There may be an increased risk of blood or kidney disorders if zidovudine is used in combination any of the following medicines, which can also decrease blood cells and have side effects on the kidneys:

- systemic pentamidine
- dapsone
- amphotericin
- flucytosine
- interferon
- vincristine
- vinblastine
- doxorubicin.

If your doctor decides you need treatment with any of these medicines while you are taking Trizivir, extra care should be taken to monitor your kidney function and levels of blood cells.

Trimethoprim may increase the blood level of lamivudine. This should not require a dose adjustment unless you have kidney problems, however you should be well monitored by your doctor if you are prescribed trimethoprim or co-trimoxazole (which contains trimethoprim) while taking this medicine. The manufacturer recommends that high doses of co-trimoxazole for the treatment of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis should be avoided in people taking this medicine.

The manufacturer recommends that this medicine is not used in combination with the following medicines:

- stavudine (zidovudine may inhibit effect of stavudine)
- ribavirin (ribavirin may inhibit effect of zidovudine)
- ganciclovir
- foscarnet
- zalcitabine.

Other medicines containing the same active ingredients

There are currently no other medicines available in the UK that contain this abacavir, lamivudine and zidovudine combination.

Ziagen contains just abacavir.

Epivir contains just lamivudine.

Retrovir contains just zidovudine.

Kivexa contains abacavir and lamivudine.

Combivir contains zidovudine and lamivudine.

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