Avandia

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

This medicine must not be used in by people treated with insulin, as this combination may increase the risk of heart failure.

If this medicine is used in dual or triple therapy, in combination with a sulphonylurea such as gliclazide, the chance of your blood sugar dropping too low (hypoglycaemia) may be increased. Your doctor may need to alter your dose of sulphonylurea to avoid this.

When this medicine is used as triple therapy, in combination with metformin and a sulphonylurea, there may also be an increased risk of fluid retention and heart failure. You can ask your doctor for more information about this. It may be more suitable to use insulin instead of triple therapy and your doctor should discuss this option with you.

There may be an increased risk of fluid retention (oedema) if non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac or ibuprofen are taken with this medicine.

Gemfibrozil may increase your blood level of rosiglitazone. If you are taking gemfibrozil in combination with rosiglitazone your doctor may therefore need to lower your rosiglitazone dose, depending on your blood sugar levels.

The following medicines may decrease the blood level of rosiglitazone and make it less effective at lowering blood sugar:

- rifampicin
- carbamazepine
- phenytoin
- phenobarbital
- the herbal remedy St John's wort.

If you are taking any of these with rosiglitazone your blood sugar should be monitored to make sure the rosiglitazone is still effective.

Other medicines containing the same active ingredients

There are currently no other medicines available in the UK that contain rosiglitazine as the sole active ingredient.

Avandamet tablets contain rosiglitazone in combination with metformin.

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