Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Rash

Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain

Pins and needles sensation in or around the mouth

Disturbed sleep

Changes in mood

Fatigue

High blood glucose level (hyperglycaemia)

Alteration in results of liver function tests

Pain in the muscles (myalgia)

Loss of appetite

Severe blistering skin reaction affecting the tissues of the eyes, mouth, throat and genitals.(Stevens-Johnson Syndrome)

Muscle breakdown (rhabdomyolysis)

Raised levels of triglycerides in the blood (hypertriglyceridaemia)

Redistribution of body fat, eg decreased fat under the skin, increased fat on the abdomen, 'buffalo humps' and breast enlargement.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Amprenavir should not be taken with the following due to a risk of serious or life threatening side effects:- - terfenadine - cisapride - pimozide - the benzodiazepines triazolam, diazepam, flurazepam and midazolam - ergotamine - dihydroergotamine The following should not be taken with amprenavir as they can make it ineffective:- - rifampicin - the herbal remedy St John's wort Ritonavir increases and efavirenz and nevirapine may reduce the blood levels of amprenavir. Dosage adjustments may be made by your doctor if ritonavir, nevirapine or efavirenz are part of your anti-HIV treatment. Delavirdine may increase the blood levels of amprenavir. Amprenavir increases the blood levels of rifabutin, therefore lower than normal doses of rifabutin may be prescribed. Doses of antacids or indinavir should be separated from amprenavir doses by at least an hour, as they may decrease the absorption of amprenavir from the gut. Amprenavir has the potential to interact with many other medicines, but as it is a new medicine, there is not yet sufficient information to determine how important these interactions might be. If the following are taken with amprenavir, they should be monitored by your doctor:- - opiate derivatives such as methadone - amiodarone - phenobarbitone, phenytoin - tricyclic antidepressants - quinidine - warfarin - the calcium channel blockers diltiazem, nicardipine, nifedipine or nimodipine - sildenafil (Viagra), whose blood levels may be increased - cholesterol lowering medicines atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin and simvastatin - clozapine, carbamazepine, erythromycin, cimetidine, dapsone, itraconazole, loratidine and benzodiazepines, whose blood levels may also be increased by amprenavir - hormonal contraceptives, which may have a reduced contraceptive effect. A barrier method of contraception should be used by women of child bearing potential.

Other medicines containing the same active ingredients

Agenerase capsules

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