Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Abdominal pain

Indigestion (dyspepsia)

Ulceration of the stomach or intestine

Bleeding from the stomach

Retention of water in the body tissues (fluid retention), resulting in swelling (oedema)

Blood disorders

Kidney disease

Inflammation of the pancreas (pancreatitis)

Severe flaking of the surface layer of the skin (toxic epidermal necrolysis)

Narrowing of the airways (bronchospasm)

Damage to the liver

Severe swelling of lips, face or tongue (angioedema)

Rash (allergic reaction)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Sulindac may enhance the effect of the following medicines, resulting in an increased risk of side-effects or toxicity: cyclosporin, lithium, methotrexate, quinolone antibiotics, zidovudine and blood-thinning or anti-clotting medicines. Sulindac may also enhance the effect of antidiabetic tablets (belonging to the sulphonylurea group), which could lead to low blood sugar levels. The effect of sulindac may be enhanced by the following medicines, resulting in an increased risk of side-effects or toxicity: dimethyl sulfoxide (DMSO) and ritonavir. The effect of water tablets (diuretics) and blood pressure lowering agents may be reduced by sulindac, resulting in their being less effective. The action of sulindac is reduced by cholestyramine. Use of sulindac with diuretics or ACE inhibitors may increase the risk of kidney problems and/or an altered potassium balance as a side effect. NSAIDs should not be used within 8-12 days of taking mifepristone. Sulindac should not be taken with any other NSAID.

Other medicines containing the same active ingredients

Clinoril

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