Night nurse

How can this medicine affect other medicines?

If you are already taking any other medicines, including herbal medicines and those bought without a prescription, you should check with your pharmacist before taking this medicine, to ensure that the combination is safe.

This medicine should not be used by people who are currently taking a monoamine oxidase inhibitor antidepressant, eg phenelzine, tranylcypromine, isocarboxazid or moclobemide, or who have taken one of these medicines in the last 14 days.

You should not take this medicine if you have already taken four doses of a paracetamol containing medicine during the day, as this can easily result in exceeding the maximum recommended daily dose of paracetamol. Many cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of any other medicines before taking them with this one.

This medicine may cause drowsiness. If this occurs, it may be made worse if the medicine is taken in combination with any of the following, which can also cause drowsiness:

alcohol

benzodiazepines, eg temazepam, diazepam

sedating antihistamines, eg chlorphenamine, diphenhydramine, triprolidine (these are often found in other non-prescription cough and cold or hayfever remedies)

sleeping tablets, eg zopiclone

strong opioid painkillers, eg codeine, dihydrocodeine, morphine

tricyclic antidepressants, eg amitriptyline.

There may be an increased risk of side effects such as dry mouth, blurred vision, constipation or difficulty passing urine if this medicine is taken with any of the following medicines:

anticholinergic medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium

anticholinergic medicines for Parkinson's disease, eg trihexyphenidyl, orphenadrine, procyclidine

antipsychotic medicines, eg chlorpromazine, clozapine

antispasmodics, eg atropine, hyoscine

certain antisickness medicines, eg prochlorperazine, meclozine, cyclizine

muscle relaxants, eg baclofen

tricyclic or related antidepressants, eg amitriptyline, maprotiline.

Cholestyramine reduces the absorption of paracetamol from the gut. It should not be taken within an hour of taking paracetamol or the effect of the paracetamol will be reduced.

Metoclopramide and domperidone may increase the absorption of paracetamol from the gut.

Long-term or regular use of paracetamol may increase the anti-blood-clotting effect of warfarin and other anticoagulant medicines, leading to an increased risk of bleeding. This effect does not occur with occasional pain-killing doses.

Other medicines containing the same active ingredients

There are currently no other medicines available in the UK that contain this combination of active ingredients.

Day & night nurse is a product that contains a combination of Day nurse capsules for daytime cold and flu symptoms and Night nurse capsules for night time symptoms.

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