Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Drowsiness

Visual disturbances

Dizziness

Nausea and vomiting

Pain in the joints (arthralgia)

Shaky movements and unsteady walk (ataxia)

Rapid involuntary movements of the eyes (nystagmus)

Skin reactions such as rash and itch

Anaemia where the cells in the bone marrow that are to form red blood cells are larger than normal, usually due to a deficiency in folic acid or vitamin B12 (megaloblastic anaemia)

Chronic inflammatory disease which affects the skin and various internal organs (systemic lupus erythematosus)

Change in personality

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

When primidone is taken with phenytoin there may be increased conversion of primidone to phenobarbital, leading to increased phenobarbital levels. The effectiveness of oral contraceptives may be reduced by primidone. Breakthrough bleeding may also occur. There may be increased drowsiness if this medicine is taken with alcohol or medicines which cause sedation such as:- antidepressants e.g. amitriptyline anxiolytics e.g. diazepam antipsychotics e.g. chlorpromazine sleeping medcines e.g. temazepam sedating antihistamines e.g. chlorpheniramine barbiturates When taken with other anticonvulsant medicines the blood levels of either medicine may be altered. The effects of adding or removing anticonvulsants to or from existing treatment should be monitored to ensure seizure control is maintained and blood levels do not become too high. The effects of the following medicines may be reduced when taken together with primidone: corticosteroids such as prednisolone anticoagulants such as warfarin fentanyl quinidine tiagabine When taken with folic acid or acetazolamide the blood level of primidone may be decreased, resulting in reduced seizure control.

Other medicines containing the same active ingredients

Mysoline

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