How can this medicine affect other medicines?
Methylphenidate may increase the blood levels of the following medicines:
- anticoagulants (blood-thinning medicines, eg warfarin)
- antiepileptic medicines, eg phenytoin, primidone, phenobarbital (phenobarbitone)
- phenylbutazone
- tricyclic antidepressants, eg imipramine
- SSRI antidepressants.
Children taking any of these medicines may need to have their doses reduced by the doctor.
If this medicine is taken within 14 days of taking a monoamine oxidase inhibitor antidepressant (MAOI, eg tranylcypramine, phenelzine) there may be a risk of a dangerous rise in blood pressure (hypertensive crisis). For this reason methylphenidate should not be taken by individuals who have taken an MAOI in the previous 14 days.
Methylphenidate may reduce the blood pressure lowering effect of antihypertensive medicines such as guanethidine, bretylium or debrisoquine.
Check with your pharmacist before giving cough and cold remedies to children taking methylphenidate, as these types of medicines sometimes contain ingredients that may affect blood pressure, and could be unsuitable to use in combination with methylphenidate.
Other medicines containing the same active ingredients
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