Health Centres - Motilium suppositories
How does it work?
This medicine contains the active ingredient domperidone, which is a type of medicine called a dopamine antagonist. It is an anti-emetic medicine, meaning it is used to treat nausea and vomiting. It can also be used to treat abdominal bloating, fullness and discomfort in adults.
What is it used for?
- Nausea and vomiting in adults and children
- Relief of upper abdominal discomfort, sense of fullness and regurgitation of stomach contents in adults
Warning!
- Motilium tablets contain lactose and may be unsuitable for people with lactose intolerance, glucose/galactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia). Motilium suspension contains sorbitol and may be unsuitable for people with sorbitol intolerance.
Use with caution in
- Decreased liver function
- Infants and young children
- Prolonged repeated use in severely decreased kidney function
Not to be used in
- Abnormal hole in the stomach or intestines (gastrointestinal perforation)
- Bleeding from the gut (gastrointestinal haemorrhage)
- Cancer of the pituitary gland resulting in over-production of the hormone prolactin (prolactinoma)
- Conditions in which stimulating movement through the stomach could be harmful (your doctor will know)
- Obstruction of the stomach or intestines
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
- The safety of this medicine for use during pregnancy has not been established. It is not recommended for use in pregnancy unless considered essential by your doctor. Seek medical advice from your doctor.
- This medicine passes into breast milk in small amounts. Seek medical advice from your doctor before breastfeeding.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
- Diarrhoea
- Abnormal enlargement of breasts in men (gynaecomastia)
- Abnormal movements of the hands, legs, face, neck and tongue, eg tremor, twitching, rigidity (extrapyramidal effects)
- Breast pain
- High blood prolactin (milk producing hormone) level (hyperprolactinaemia). Sometimes this can lead to symptoms such as breast enlargement, production of milk and stopping of menstrual periods.
- Stomach cramps
- Decreased sex drive
- Itchy rash (urticaria)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

