Solpaflex

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Ibuprofen should not be taken in combination with painkilling doses of aspirin or any other NSAID (eg naproxen, diclofenac) that is taken by mouth, as this increases the risk of side effects on the stomach and intestines. This medicine should not be taken by people taking selective inhibitors of COX-2, such as celecoxib or etoricoxib, for the same reason.

There may be an increased risk of ulceration or bleeding from the gut if ibuprofen is taken with corticosteroids such as prednisolone.

There may also be an increased risk of bleeding from the gut if ibuprofen is taken with the following medicines:

anti-blood-clotting (anticoagulant) medicines such as warfarin

antiplatelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, dipydridamole, clopidogrel

SSRI antidepressants, eg fluoxetine, paroxetine, citalopram

venlafaxine.

There may be an increased risk of side effects on the kidneys if ibuprofen is taken in combination with any of the following medicines:

ACE inhibitors, eg enalapril

ciclosporin

diuretics, eg furosemide

tacrolimus.

Ibuprofen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines:

digoxin

lithium

methotrexate.

Ibuprofen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:

amlodipine

ACE inhibitors such as captopril

beta-blockers such as atenolol.

Other medicines containing the same active ingredients

Cuprofen plus

Nurofen plus

Solpadeine migraine

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