How does it work?

Sodium polystyrene sulphonate is a sodium containing compound known as an ion-exchange resin. The sodium contained in this compound is exchanged for potassium in the body. Sodium polystyrene sulphonate acts in the gut to exchange its sodium for any potassium present in the gut. This includes the potassium consumed in the diet and the potassium that is secreted into the gut and then reabsorbed into the blood as part of the normal function of the body. Potassium binds to the ion-exchange resin, preventing its absorption into the blood. All the potassium that is bound to the ion-exchange resin is then excreted from the body as faeces. The overall effect is a decrease in absorption of potassium from the gut, which results in decreased blood potassium levels. Therefore, this medicine is used to reduce high blood potassium levels (hyperkaelemia). High blood potassium levels may occur in people who have decreased kidney function. This is because the kidneys normally filter salts (such as potassium) and water from the blood to form urine. This may also occur in people with kidney failure requiring regular dialysis. Sodium polystyrene sulphonate can be given either by mouth as a suspension or rectally as an enema.

What is it used for?

High levels of potassium in the blood (hyperkalaemia)

Warning!

Do not give the oral suspension of this medicine with fruit squash drink (as these types of drink contain large amounts of potassium).

If significant constipation occurs, this medicine should be discontinued.

If constipation occurs, do not take magnesium containing laxatives.

Do not use sorbitol when making an enema suspension with this medicine.

Suspensions prepared with this medicine should be freshly prepared and should not be stored for longer than 24 hours.

This medicine must not be given orally to infants less than one month old.

It is important have regular blood tests when taking this medicine to monitor blood salt levels and determine the required dose of this medicine.

Use with caution in

Babies less than one month old (neonates)

Children

Congestive heart failure

High blood pressure

Kidney disease

People taking digoxin

Swelling due to excess fluid retention (oedema)

Not to be used in

Blood potassium level less than 5mmol/L

Disease causing obstruction of the bowel (obstructive bowel disease)

Infants under one month of age with decreased gut movement (e.g. after surgery or due to medicines)

People with an allergy to polystyrene sulphonate compounds

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The medicine should not be used during pregnancy or breastfeeding unless considered essential by your doctor. Seek medical advice.

Label warnings

Dissolve or mix this medication with water before taking.

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