How does it work?

Misoprostol belongs to a group of medicines known as 'prostaglandin analogues'. Misoprostol is a synthetic compound similar to prostaglandin E1 (alprostadil) which is one of a group of chemicals (the prostaglandins) found in the body. Prostaglandin E1 is involved in protecting the lining of the stomach. Misoprostol mimicks the action of prostaglandin E1 in the body. It is used in the treatment of gastro-intestinal ulcers including those occurring in people who are taking one of a group of medicines known as 'non-steroidal anti-inflammatory drugs (NSAIDs)' to manage their arthritis. One of the adverse effects of NSAIDs is stomach and duodenal ulcers (gastro-intestinal ulceration). Unfortunately misoprostol also mimicks the labour-inducing effects of prostaglandin E1. Therefore women who are pregnant or who may become pregnant should avoid taking misoprostol as it may cause contractions of the uterus.

What is it used for?

Stomach (gastric) and duodenal ulcers

Ulcer caused by a non-steroidal anti-inflammatory drug

Warning!

This medicine should not be used in women of child-bearing age unless she requires NSAID therapy and is at risk of complications from NSAID induced ulcers: in which case effective contraceptive measures should be taken.

Use with caution in

Coronary artery disease

Disease of the blood vessels in and around the brain (cerebrovascular disease)

High blood pressure

Not to be used in

Allergy to any of the active ingredients

Children

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should not be used in pregnancy. Seek medical advice from your doctor.

There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Label warnings

Take this medication with or after food.

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