How does it work?

Molgramostim is a substance that stimulates the production of a type of white blood cell from the bone marrow, known as neutrophils. Neutrophils play a cental role in the body's immune system and defends the body from infections. Therefore a low level of neutrophils in the blood (neutropenia), leaves a person very susceptible to life threatening infections. Neutropenia can be caused by a number of factors, such as cancer chemotherapy and it often occurs in individuals who have recently had a bone marrow transplant or are suffering from AIDS. Molgramostim is commonly used after high dose chemotherapy regimes or bone marrow transplants, to correct low neutrophil levels in the blood and thereby reduces the duration and severity of the neutropenia. As a result, molgramostim minimises the need for antibiotic treatment, the risk of complications due to infections and length of time spent in hospital after bone marrow transplants.

What is it used for?

To speed up production of a type of white blood cell (neutrophils) following bone marrow transplants

Very low levels of a type of white blood cell (neutrophils) in the blood caused by ganciclovir (ganciclovir-induced neutropenia) in individuals suffering from AIDS.

Very low levels of a type of white blood cell (neutrophils) in the blood caused by medicines used to treat cancers (chemotherapy induced neutropenia)

Warning!

For use only under specialist medical supervision

People taking this medicine should have regular blood tests to check the levels of their blood components.

Use with caution in

Children and adolescents under 18 years of age

Diseases caused by the body's immune system attacking itself (autoimmune diseases such rheumatoid arthritis)

Lung disease

Not to be used in

Cancer of the blood involving white blood cells from the myeloid family

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

There is no information available about the safety of this medicine during pregnancy, therefore it is not recommended for use during pregnancy, unless considered essential by your doctor. Seek medical advice from your doctor.

There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Rash

Abdominal pain

Diarrhoea

Fatigue

Blood disorders

Fever (pyrexia)

Nausea and vomiting

Pain in muscles or bones (musculoskeletal pain)

Reactions at injection site

Difficulty in breathing (dyspnoea)

Chest pain

An extreme allergic reaction (anaphylaxis)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

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