How can this medicine affect other medicines?

The following medicines may increase the removal of corticosteroids from the body, thus reducing their effects:- - antiepileptics e.g. carbamazepine, phenytoin and primidone - barbituates e.g. phenobarbitone - rifampicin - aminoglutethimide When taken with carbenoxolone, acetazolamide, amphotericin or diuretics e.g. frusemide there is an increased risk of low blood potassium levels (hypokalaemia). When taken with non-steroidal anti-inflammatory drugs (NSAIDs) e.g. indomethacin, there is an increased risk of adverse effects on the gut, such as stomach ulceration and bleeding. The blood levels of salicylates e.g. aspirin, are decreased by corticosteroids and therefore may increase to excessive levels once the corticosteroid is stopped. Corticosteroids may oppose the treatment of high blood pressure and heart failure, as they may cause retention of salt and water. As corticosteroids may increase blood sugar, they can oppose the blood sugar lowering effects of antidiabetic medicines. Live vaccines should not be administered to people taking corticosteroids, as their normal immune response is reduced and giving a live vaccine may therefore result in infection rather than the production of antibodies.

Other medicines containing the same active ingredients

Hydrocortistab injection

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