How can this medicine affect other medicines?

When taken together with cisapride, sertindole, sotalol, astemizole, terfenadine or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of abnormal heart rhythm, if low blood potassium (hypokalaemia) occurs with hydrochlorothiazide. If hypokalaemia does not occur, this risk is removed. If hypokalaemia occurs with hydrochlorothiazide, the adverse effects of cardiac glycosides such as digoxin may be increased. When taken together with other medicines which can cause hypokalaemia e.g. corticosteroids, carbenoxolone or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of developing hypokalaemia. Potassium supplements may be required. If used with other diuretics, the fluid and salt (electrolyte) balance in the body should be monitored. When taken together with medicines that decrease blood pressure there is an increased risk of a large drop in blood pressure. Hydrochlorothiazide reduces the ability of the body to remove the medicine lithium. As this can give rise to adverse effects, this medicine should not be taken with lithium. This medicine may raise blood glucose levels and therefore reduce the effectiveness of antidiabetic medicines. Dose adjustments of the antidiabetic may be required. Cholestyramine and colestipol reduce the absorption of this medicine from the gut if taken at the same time.

Other medicines containing the same active ingredients

HydroSaluric

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