Flagyl suppositories

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How does it work?

Flagyl suppositories contain the active ingredient metronidazole, which is a type of medicine called an antibiotic. (NB. Metronidazole is also available without a brand name, ie as the generic medicine.) Metronidazole is used to treat infections caused by bacteria and other micro-organisms called protozoa.

Metronidazole works by entering bacterial and protozoal cells and interfering with their genetic material (DNA). It damages the DNA and also prevents the bacteria and protozoa from forming new DNA. This ultimately results in metronidazole killing the micro-organisms, which clears up the infection.

Metronidazole kills a wide variety of bacteria that are known collectively as anaerobic bacteria. This means that they do not need oxygen to grow and multiply. Anaerobic bacteria can cause infections in areas of the body such as the bones, gut, pelvic cavity and gums. Metronidazole is used to treat these types of infections.

Metronidazole is also used to prevent infection following surgery, particularly gynaecological surgery and surgery on the gut, where many anaerobic bacteria may be found. In high doses, metronidazole penetrates the brain and can be used to treat abscesses in the brain.

To make sure the micro-organisms causing an infection are susceptible to metronidazole your doctor may take a tissue sample, for example a swab from the infected area.

Flagyl suppositories are used when administration of metronidazole by mouth is not possible. The metronidazole is absorbed into the bloodstream from the rectum.

What is it used for?

- Preventing and treating infections with anaerobic bacteria following surgery, particularly surgery on the gut or gynaecological surgery
- Bacterial infection of the blood (septicaemia or blood poisoning)
- Bacterial infection of the blood following childbirth (puerperal fever/sepsis)
- A serious form of pneumonia (necrotising pneumonia)
- Bacterial infections of bone (osteomyelitis)
- Bacterial infections in the abdomen (peritonitis)
- Abscess in the pelvic cavity, usually a result of an abdominal infection
- Inflammation of the connective tissue and muscle around the uterus due to bacterial infection (pelvic cellulitis)
- Brain abscesses

Warning!

- Flagyl suppositories are for rectal use only and should not be taken by mouth.
- You should not drink alcohol while using this antibiotic, and for at least 48 hours after finishing the course, as this can cause unpleasant symptoms such as hot flushes, abdominal cramps, nausea, vomiting, headache and palpitations.
- This medicine may cause various side effects that could impair your mental or physical ability to safely drive or operate machinary. You should be aware of how you react to this medicine before driving or operating machinary.
- Unless your doctor tells you otherwise, it is important that you finish the prescribed course of this antibiotic medicine, even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic.
- If your treatment course exceeds 10 days it is recommended that you are monitored by your doctor, who may carry out tests to check for side effects and that the medicine is working properly.

Use with caution in

- Decreased liver function
- Brain disease that has occured as a result of liver disease
- Hereditary blood disorders called porphyrias

Not to be used in

- Known sensitivity or allergy to any ingredient

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- The safety of this medicine during pregnancy has not been fully established. It should only be used during pregnancy if considered essential by your doctor because no safer antibiotics are suitable or available. High dosage regimens should be avoided. Seek medical advice from your doctor.
- This medicine passes into breast milk. It should be used with caution in breastfeeding mothers and only if the expected benefit to the mother is greater than any possible risk to the nursing infant. High dosage regimens should be avoided unless the mother stops breastfeeding during the course. Seek medical advice from your doctor.

Label warnings

- Avoid alcoholic drink whilst taking this medication.
- Take at regular intervals. Complete the prescribed course unless otherwise directed.

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