How does it work?

This medicine contains two active ingredients, aspirin and papaveretum. Aspirin belongs to a class of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise cause swelling, pain and inflammation. Papaveretum belongs to a group of medicines called opioids. Opioids mimic the effects of naturally occurring pain reducing chemicals (endorphins) that are found in the brain and spinal cord. They combine with the opioid receptors in the brain and block the transmission of pain signals. Therefore, even though the cause of the pain may remain, less pain is actually felt.

What is it used for?

Moderate to severe pain following surgery

Pain associated with cancer

Warning!

This medication should be discontinued several days prior to surgery.

Use with caution in

Abnormal muscle weakness

Allergic diseases

Anaemia

Asthma

Dehydration

Enlarged prostate gland

Epilepsy

Gall bladder disease or gall stones

Gout

Head injury

Heart failure

History of alcoholism or drug abuse

Hypothyroidism

Increased pressure in the brain (raised intracranial pressure)

Inflammatory bowel disease such as ulcerative colitis or Crohn's disease

Kidney disease

Lack of production of natural steroid hormones from the adrenal gland (adrenocortical insufficiency)

Lack of the chemical G6PD in the blood (G6PD deficiency)

Liver disease

Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)

Low blood pressure (hypotension)

Recent gut surgery

Thyrotoxicosis

Tumour of the adrenal gland (phaeochromocytoma)

Not to be used in

Allergy to aspirin or other medicines in this class

Allergy to opioid painkillers

Bleeding disorders

Children under 12 years of age, unless prescribed by a doctor

Diarrhoea due to poisoning or certain antibiotics

Disease affecting the airways or lungs (respiratory disease)

Growths into the nose (nasal polyps) associated with asthma

History of stomach or duodenal ulcers or indigestion

Peptic ulcers

Severe liver disease

Slow, shallow breathing (respiratory depression)

Sudden asthma attack

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than the possible risk to the foetus. Seek medical advice from your doctor.

This medicine passes into breast milk. It is recommended that mothers should avoid using this medicine while breastfeeding. Seek medical advice from your doctor.

Label warnings

Dissolve or mix this medication with water before taking.

Take this medication with or after food.

This medication contains aspirin.

This medication may cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink.

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