How can this medicine affect other medicines?

When taken together with cisapride, sertindole, sotalol, astemizole, terfenadine or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of abnormal heart rhythm, if low blood potassium (hypokalaemia) occurs with metolazone. If hypokalaemia does not occur, this risk is removed. If hypokalaemia occurs with metolazone, the toxicity of cardiac glycosides such as digoxin may be increased. When taken together with other medicines which can cause hypokalaemia e.g. corticosteroids, carbenoxolone or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of developing hypokalaemia. Potassium supplements may be required. If used with other diuretics, the fluid and salt (electrolyte) balance in the body should be monitored. When taken together with medicines that decrease blood pressure there is an increased risk of a large drop in blood pressure. When taken together with frusemide a profound loss of fluid can occur.

Other medicines containing the same active ingredients

Metenix 5

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