Zomig

How does it work?

Zomig tablets contain the active ingredient zolmitriptan, which is a type of medicine called a serotonin (or 5HT) agonist. This type of medicine is also commonly known as a 'triptan'. It is a painkiller specifically used to relieve migraine attacks.

Although the cause of migraine attacks is not fully understood, it is thought that widening of blood vessels in the brain causes the throbbing pain of migraine headaches. Zolmitriptan relieves this pain by causing the blood vessels in the brain to narrow.

Zolmitriptan works by stimulating receptors called serotonin (or 5HT) receptors that are found in the brain. A natural substance called serotonin normally acts on these receptors, causing blood vessels in the brain to narrow. Zolmitriptan mimics this action of serotonin by directly stimulating the serotonin receptors in the brain. This narrows the blood vessels and so relieves the pain of migraine headaches.

The dose of zolmitriptan should be taken as early as possible after the migraine headache has started, though it is also effective if taken at a later stage during the migraine attack.

Zomig tablets usually provide significant relief from the migraine within an hour of taking them.

What is it used for?

Relieving migraine attacks

Warning!

This medicine should not be used to prevent migraines.

This medicine should only be used by people with a clear diagnosis of migraine from their doctor.

If your migraine symptoms persist or return after one dose, a second dose can be effective. If you need a second dose, you should NOT take it within two hours of the first dose. Do not exceed the recommended dose. The maximum recommended dose in 24 hours is 10mg, unless you have liver problems, or are taking certain other medicines (see below). Discuss this with your doctor.

This medicine can cause feelings of warmth, heaviness, pressure, tightness or pain in certain parts of the body, including the chest or throat. Although sometimes very strong, these feelings usually only last a few minutes. If they continue or are particularly severe (especially chest pain), you should tell your doctor immediately, as there have been extremely rare reports of such problems being caused by a heart attack. Do NOT take another dose; your doctor will decide if you should stop using this medicine.

This medicine might make you feel sleepy and so may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.

The safety and efficacy of this medicine have not been established in children and in elderly people over 65 years of age. It is not recommended for these age groups.

Use with caution in

Decreased liver function

High blood pressure

People with risk factors for ischaemic heart disease, such as smoking, high cholesterol levels, diabetes, obesity, or a family history of heart disease

Not to be used in

Heart disease caused by inadequate blood flow to the heart (ischaemic heart disease), eg angina

People who have had a heart attack

A severe form of angina pectoris, not caused by exertion (Prinzmetal's angina)

Uncontrolled high blood pressure

History of stroke

History of small temporary strokes (transient ischaemic attacks)

Abnormal heart beats caused by Wolff-Parkinson-White syndrome

Irregular heart beats (arrhythmias)

A form of migraine associated with temporary paralysis of one side of the body (hemiplegic migraine)

A type of migraine where there is a disturbance in brain function which initially presents with total blindness followed by dizziness, speach disturbances, ringing in the ears and double vision (basilar migraine)

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The safety of this medicine in pregnancy has not been established. It should only be used by pregnant women if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.

It is not known if this medicine passes into breast milk. It should be used with caution in nursing mothers, and only if the benefits to the mother outweigh any risks to the nursing infant. Discuss this with your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Sensation of tightness, pressure, tingling, heaviness, heat or pain in any part of the body, including the chest and throat (see warning above)

Dry mouth

Nausea

Muscle pain and weakness

Abnormal sensations or disturbance of sensation, eg pins and needles

Dizziness

Sleepiness (somnolence)

Weakness or loss of strength (asthenia)

Increased heart rate (tachycardia)

Awareness of your heart beat (palpitations)

Headache

Hives

Swelling of the face, lips or tongue (angioedema)

Increases in blood pressure

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

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