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Vomiting is controlled by an area of the brain called the vomiting centre. The vomiting centre is responsible for causing feelings of sickness (nausea) and for the vomiting reflex. It is activated when it receives nerve messages from another area of the brain called the chemoreceptor trigger zone (CTZ) and when it receives nerve messages from the gut.
Chemotherapy, radiotherapy and surgery can cause a substance called serotonin (5HT) to be released in the gut. This 5HT acts on the 5HT
5HT released by chemotherapy, radiotherapy and surgery also activates the 5HT
Ondansetron works by blocking the 5HT
Zofran melt tablets are designed to dissolve rapidly on the tongue and be swallowed with the saliva, without the need for a drink of water. Ondansetron can also be given by standard tablets or syrup, suppository, injection into a muscle or vein, or by drip (infusion) into a vein. See the factsheets linked at the end of this article for more information about these dose forms.
What is it used for?
Warning!
Use with caution in
Not to be used in
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
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