Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Rash
Slower than normal heart beat (bradycardia)
Inability of the heart to pump blood efficiently (heart failure)
Disturbed sleep
Impotence
Blood disorders
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Cold extremities, eg hands and feet
False perceptions of things that are not really there (hallucinations)
Dizziness
Breathing difficulties due to a narrowing of the airways (bronchospasm)
Disturbances in the levels of chemical components (electrolytes) in the blood
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
When taken together with medicines that decrease blood pressure there is an increased risk of a large drop in blood pressure.
When taken together with cisapride, sertindole, sotalol, astemizole, terfenadine or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of abnormal heart rhythm, if low blood potassium (hypokalaemia) occurs with clopamide. If hypokalaemia does not occur, this risk is removed.
When taken together with other medicines which can cause hypokalaemia e.g. corticosteroids, carbenoxolone or beta-agonist bronchodilators such as salbutamol, there may be an increased risk of developing hypokalaemia. Potassium supplements may be required.
When taken together with cardiac glycosides such as digoxin, there is an increased risk of adverse effects, if hypokalaemia occurs with clopamide. There is also an increased risk of extremely slow heart rate when pindolol is taken with digoxin.
Clopamide reduces the ability of the body to remove the medicine lithium. As this may give rise to adverse effects, this medicine should not be taken with lithium.
In diabetic patients, pindolol can prolong the lowering of blood sugar (hypoglycaemia) caused by insulin or other antidiabetic medicines. Individuals should monitor their blood sugar, as pindolol can also mask the signs of hypoglycaemia. Clopamide may increase blood sugar.
When pindolol is taken together with calcium channel blockers such as verapamil or diltiazem, the risk of slow heart rate, hypotension and heart failure may be increased. Verapamil should not be taken with this medicine and other calcium channel blockers should not be given intravenously (injection into a vein).
When taken with calcium channel blockers such as nifedipine there may be a risk of very low blood pressure.
For further information on the interactions with the pindolol component of this medicine, please refer to the pindolol medicine entry.
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