Trandate

How does it work?

Labetalol belongs to a group of medicines called beta-blockers, which block beta receptors in the heart, lungs and other organs of the body. Blocking these receptors prevents the action of two chemicals called noradrenaline and adrenaline that occur naturally in the body. These are often referred to as the 'fight or flight' chemicals as they are responsible for the body's reaction to stressful situations. Blocking the beta receptors in the heart causes the heart to beat more slowly and with less force. The heart therefore uses less energy and the pain of angina is prevented. Due to the heart beating more slowly and with less force, the pressure at which blood is pumped out of the heart to the rest of the body is reduced. This medicine also widens the arteries. These are two of the ways in which labetolol helps to reduce blood pressure, however the whole mechanism is not fully understood. Labetolol is used to treat high blood pressure and also to cause controlled low blood pressure during anaesthesia.

What is it used for?

Dangerously high blood pressure

High blood pressure

High blood pressure with angina, following a heart attack or in pregnancy

Warning!

This medicine may mask the symptoms of low blood sugar such as increased heart rate, tremor and nausea. People with diabetes should carefully monitor their blood sugar.

Use with caution in

Abnormal muscle weakness

Defect of the heart's electrical message pathways resulting in decreased function of the heart (heart block)

Diabetes

History of allergies

Kidney disease

Not to be used in

A problem common in the elderly, related to poor control of the working of the heart (sick sinus syndrome)

Angina not well controlled by medical treatment

Asthma

Blockage of arteries in the extremities

Chronic obstructive pulmonary disease

Failure of the heart to maintain adequate circulation of blood (cardiogenic shock)

Heart failure

Increased acid levels in the blood (metabolic acidosis)

Liver disease

Low blood pressure (hypotension)

Tumour of the adrenal gland (phaeochromocytoma)

Very slow heart rate (severe bradycardia)

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.

This medicine should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than any possible risk to the baby. Seek medical advice from your doctor.

Label warnings

Do not stop taking this medication except on your doctor's advice.

Take this medication with or after food.

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