Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Headache
Blurred vision
Dry mouth
Drowsiness
Blood disorders
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Weight gain
Alteration in results of liver function tests
False perceptions of things that are not really there (hallucinations)
Retention of water in the body tissues (fluid retention)
Dizziness
Severe blistering skin reaction affecting the tissues of the eyes, mouth, throat and genitals.(Stevens-Johnson Syndrome)
Shaky movements and unsteady walk (ataxia)
Allergic skin reactions
Double vision
Liver or kidney disorders
Abnormal involuntary movements (twitching or tics)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
Carbamazepine can interact with many medicines and the dose of carbamazepine or the interacting medicine may need to be altered as a result. It is important to tell your doctor what medicines you are taking, including herbal medicines and those bought without a prescription, before you start carbamazepine. Likewise, once you are taking carbamazepine it is important to check with your doctor or pharmacist before you start taking any new medicines, or stop taking any existing medicines.
Carbamazepine blood levels may be increased by:
- acetazolamide
- azole antifungals, eg fluconazole, ketoconazole
- cimetidine
- danazol
- dextropropoxyphene
- diltiazem
- fluoxetine
- fluvoxamine
- haloperidol
- isoniazid
- macrolide antibiotics, eg erythromycin, clarithromycin
- nefazadone
- nicotinamide
- protease inhibitors (HIV), eg ritonavir
- terfenadine
- verapamil
- viloxazine.
Sodium valproate and lamotrigine may increase the rate that carbamazepine is converted to another active form in the body. This can result in an increase in carbamazepine side effects.
Carbamazepine blood levels may be decreased by:
- chemotherapy medicines, eg cisplatin, doxorubicin
- isotretinoin
- phenytoin
- phenobarbitone
- primidone
- theophylline
- rifampicin
- sodium valproate
- St John's wort.
Carbamazepine may decrease the blood levels and effectiveness of the following:
- benzodiazepines, eg alprazolam, clonazepam, diazepam, midazolam
- calcium channel blockers, eg felodipine, nimodipine
- corticosteroids, eg dexamethasone, prednisolone
- ciclosporin
- clozapine
- doxycycline
- ethosuximide
- gestrinone
- haloperidol
- itraconazole
- lamotrigine
- methadone
- oestrogens
- olanzapine
- oxcarbazepine
- paracetamol
- primidone
- progestogens
- protease inhibitors (HIV), eg indinavir, saquinavir
- risperidone
- tricyclic antidepressants such as imipramine
- theophylline
- thyroid hormones
- tiagabine
- tibolone
- topiramate
- toremifene
- tramadol
- sodium valproate
- warfarin.
Carbamazepine may raise or lower blood levels of phenytoin.
Carbamazepine should not be taken with monoamine oxidase inhibitor antidepressants (MAOIs). At least two weeks should pass after stopping an MAOI before starting carbamazepine.
There may be a decrease in blood sodium levels if carbamazepine is taken with diuretics such as frusemide and hydrochlorothiazide.
If carbamazepine is taken with lithium or haloperidol there may be an increase in brain and nervous system side effects, eg confusion, drowsiness, weakness, lethargy and tremor.
If carbamazepine is taken with isoniazid there may be an increased risk of liver disorders.
Other medicines containing the same active ingredients
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