Tagamet (cimetidine)

How can this medicine affect other medicines?

Cimetidine can increase the blood levels of various other medicines by slowing their breakdown by the liver. You should tell your doctor or pharmacist what medicines you are taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. This is particularly important if you taking any of the medicines mentioned below, because your doctor may need to monitor your treatment or alter your medicine doses. Similarly, you should check with your doctor or pharmacist before taking any new medicines during treatment with this one, to ensure that the combination is safe.

Cimetidine increases the blood levels of the following medicines and may therefore increase the risk of their side effects:

- medicines to prevent blood clots (oral anticoagulants) such as warfarin
- phenytoin
- theophylline
- aminophylline
- intravenous lidocaine
- diltiazem
- nifedipine
- procainamide
- quinidine
- epirubicin
- fluorouracil
- erythromcin
- tricyclic antidepressants such as amitryptyline or imipramine
- moclobemide.

Due to its effect on the acidity in the stomach, cimetidine may reduce the absorption of the following antifungal medicines from the stomach, which could make them less effective at treating infection:

- itraconazole
- ketoconazole.

Other medicines containing the same active ingredient

Tagamet injection

Cimetidine tablets and oral solution are also available without a brand name, ie as the generic medicine.

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