Synarel

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How does it work?

Nafarelin is a medicine that is similar to a hormone produced naturally in the brain, known as gonadotrophin releasing hormone (GnRH), but possesses a more potent action. Gonadotrophin releasing hormone acts on a gland in the brain (pituitary gland) to control the production and release of other hormones, particularly those that act on the ovaries and testes. This causes an increase in production of oestrogen (female sex hormone) and testosterone (male sex hormone). Nafarelin alters the level of sex hormones in the body. This alteration of hormone levels can be exploited to treat disorders which are linked to sex hormone levels, such as in endometriosis. Endometriosis is a disorder of the lining of the uterus (endometrium) where tissue resembling the endometrium is found in other areas of the body. Endometriosis can be controlled by the level of oestrogen. nafarelin is useful in treating endometriosis lesions and the pain often associated with it. Nafarelin is also used to treat infertility by stimulating the ovaries prior to in-vitro fertilisation.

What is it used for?

- Endometriosis
- Infertility

Warning!

- For use only under specialist medical supervision
- Exclude pregnancy before starting treatment by performing a pregnancy test.
- This medicine may be harmful to an unborn baby. Women of child-bearing age should use a reliable contraceptive method to prevent pregnancy while using this medicine.
- This medicine is to be sprayed into the nostril(s) only.
- This medicine may cause a decrease in bone density (bone loss). Therefore the manufacturers advise that repeated treatment or use for longer than 6 months is not recommended.
- Sneezing during or immediately after dosing, may reduce absorption of this medicine and may require repeat dosing.

Use with caution in

- Osteoporosis
- Polycystic ovary syndrome

Not to be used in

- Breastfeeding
- Children or adolescents under 18 years of age
- Pregnancy
- Vaginal bleeding of unknown cause

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- This medicine should not be used in pregnancy. Seek medical advice from your doctor.
- There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Label warnings

- Follow the printed instructions you have been given with this medication.

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