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There may be an increased risk of drowsiness and sedation if diazepam is taken with any of the following (which can also cause drowsiness):
- alcohol
- tricyclic antidepressants, eg amitriptyline
- MAOI antidepressants, eg phenelzine
- antipsychotics, eg chlorpromazine, clozapine
- opioids, eg morphine, codeine, dihydrocodeine
- other benzodiazepines, eg temazepam
- barbiturates, eg phenobarbital
- sedating antihistamines, eg chlorphenamine
- sleeping tablets.
The following medicines may increase the blood level of diazepam and may therefore increase its sedative effects:
- cimetidine
- disulfiram
- isoniazid
- fluvoxamine
- omeprazole
- ritonavir.
Your doctor may need to prescribe a lower than normal dose of diazepam if you are taking any of these medicines.
The following medicines may decrease the blood level of diazepam, making it less effective:
- phenytoin
- rifampicin.
Your doctor may need to prescribe a larger than normal dose of diazepam if you are taking any of these medicines.
Caffeine and theophylline may reduce the sedative and anxiety-reducing effects of diazepam.
Diazepam may reduce the effectiveness of levodopa in treating Parkinson's disease.
Diazepam may increase or decrease blood phenytoin levels.
Other medicines containing the same active ingredients
| Diazemuls | Diazepam | Valclair |