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This medicine should not be taken with beta-blockers, such as atenolol, propranolol or timolol. This is because beta-blockers have an opposite action to this medicine and cause the airways to narrow. This can result in breathing difficulties for people with asthma or COPD. This problem has sometimes been seen with eye drops containing beta-blockers, eg used for glaucoma.
Salmeterol can potentially cause a serious decrease in the levels of potassium in the blood (hypokalaemia), which may result in adverse effects. This effect can be increased by the following medicines, which can also lower potassium in the blood:
- xanthine derivates, such as theophylline or aminophylline
- corticosteroids, such as beclometasone and prednisolone
- other beta 2 agonists, such as salbutamol
- diuretics, such as bendroflumethiazide and furosemide.
This is why people with severe asthma or COPD, who may be taking several of these medicines, should have their blood potassium levels monitored regularly.
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain salmeterol as the sole active ingredient.
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