Semi-daonil (discontinued in the UK - October 2007)

How can this medicine affect other medicines?

Many medicines can affect blood sugar levels. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The following medicines may enhance the blood sugar lowering effect of this medicine and therefore increase the chance of low blood sugar (hypoglycaemia):

ACE inhibitors, eg captopril (these can cause unpredictable drops in blood sugar)

anabolic steroids, eg testosterone, nandrolone, stanozolol

chloramphenicol

cimetidine

ciprofloxacin

co-trimoxazole

disopyramide

fenfluramine

fibrates, eg clofibrate

fluconazole

fluoxetine

insulin

MAOI antidepressants, eg phenelzine

miconazole

octreotide

phenylbutazone

large doses of salicylates, eg aspirin (small pain relieving doses do not normally have this effect).

Beta-blockers, eg propranolol (including eye drops containing beta-blockers) can mask some of the signs of low blood sugar, such as increased heart rate and tremor. They also prolong episodes of low blood sugar and impair recovery back to normal glucose levels.

The warning symptoms of hypoglycaemia may also be masked by clonidine.

The following medicines may increase blood glucose levels. If you start treatment with any of these your dose of this medicine may therefore need increasing:

some antipsychotic medicines, eg chlorpromazine, olanzapine

corticosteroids, eg hydrocortisone, prednisolone

danazol

diuretics, especially thiazide diuretics, eg bendroflumethiazide

lithium

isoniazid

oestrogens and progesterones, such as those contained in oral contraceptives

protease inhibitors, eg ritonavir

somatropin (human growth hormone).

Rifampicin may reduce the blood level of this medicine. If you are prescribed rifampicin, your dose of this medicine may need to be increased to control your blood sugar.

This medicine may enhance the anti-blood-clotting effect of warfarin.

Other medicines containing the same active ingredient

Daonil

Glibenclamide tablets are also available without a brand name, ie as the generic medicine.

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