Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Rash
Diarrhoea
Allergy to active ingredients (hypersensitivity)
Red colouration of urine
Yellowing of the skin and eyes (jaundice)
Seizures (convulsions)
Alteration in results of liver function tests
Loss of contact with reality (psychosis)
Excessive breakdown of red blood cells that reduces red blood cell count (haemolytic anaemia)
Cold or flu-like symptoms
Nausea and vomiting
Inflammation of the liver (hepatitis)
"Pins and needles" sensation in hands and feet (peripheral neuritis)
Loss of appetite
Shortness of breath
Sudden severe deficiency in the number of white blood cells in the blood (agranulocytosis)
Decrease in the number of platelets in the blood (thrombocytopenia)
Inflammation of the optic nerve (the nerve connecting the eye to the brain) which results in blurring of vision (optic neuritis)
Kidney failure
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
Rifampicin and isoniazid reduce the effect of the following medications (interacting medicine in brackets):
-Methadone (rifampicin)
-Anti-arrhythmics disopyramide, mexiletine, propafenone and quinidine (rifampicin)
-Anti-bacterials chlorampheicol and dapsone (rifampicin)
-Blood thinning drugs nicoumalone and warfarin (rifampicin)
-Antidiabetic medicines chlorpropamide, tolbutamide and possibly other sulphonylurea antidiabetic drugs, and repaglinide (rifampicin)
-Anti-epileptic phenytoin (rifampicin)
-Anti-fungals fluconazole, itraconazole, terbinafine (rifampicin) and ketoconazole (both)
-Anti-virals indinavir, efavirez, nelfinavir and saquinavir (rifampicin)
-Atovaquone (rifampicin)
-Calcium channel blockers diltiazem, nifedipine, verapamil and possibly isradipine, nicardipine and nisoldipine (rifampicin)
-Corticosteroids (rifampicin)
-Cyclosporin (rifampicin)
-Oral contraceptives (rifampicin)
-Tacrolimus (rifampicin)
-Cimetidine (rifampicin)
Isoniazid increases the effects of the following medications:
-Carbamazepine
-Ethosuxamide
-Phenytoin
The following medications reduce the effectiveness of rifampicin:
-Ketoconazole
Rifampicin may cause transplant rejection when given with azathioprine.
Increased risk of liver damage if taken with carbamazepine (isoniazid).
Increased risk of toxicity if taken with cycloserine (isoniazid).
Increased level of theophylline in the blood may occur (isoniazid).
Increased risk of liver damage if used with the anaesthetic isoflurane (isoniazid).
Other medicines containing the same active ingredients
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