Oruvail

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Disturbances of the gut, such as indigestion, nausea, vomiting, constipation, diarrhoea, heartburn, abdominal pain
- If given as injection - pain or burning at injection site
- Headache
- Dizziness
- Confusion
- Drowsiness
- Balance disorders involving the inner ear (vertigo)
- Pins and needles sensations
- Retention of water in the body tissues (fluid retention), resulting in swelling (oedema)
- Mood changes
- Difficulty sleeping (insomnia)
- Ulceration of the stomach or intestine
- Bleeding from the stomach or intestine
- Allergic reactions such as skin rashes, swelling of the lips, tongue and throat (angioedema) or narrowing of the airways (bronchospasm)
- Abnormal reaction of the skin to light, usually a rash (photosensitivity)
- Kidney, liver or blood disorders
- Visual disturbances
- Sensation of ringing or other noise in the ears (tinnitus)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Ketoprofen should not be taken in combination with painkilling doses of aspirin or any other oral NSAID, eg ibuprofen, as this increases the risk of side effects on the stomach and intestines. Selective inhibitors of COX-2 such as celecoxib or etoricoxib should also be avoided for the same reason.

There may be an increased risk of ulceration or bleeding from the gut if ketoprofen is taken with corticosteroids such as prednisolone.

There may also be an increased risk of bleeding from the gut if ketoprofen is taken with the following medicines:

- anti-blood-clotting (anticoagulant) medicines such as warfarin
- anti-platelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, clopidogrel, dipyridamole
- SSRI antidepressants, eg fluoxetine, paroxetine, citalopram
- venlafaxine.

Ketoprofen may enhance the effect of blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. As this may increase the risk of bleeding, people taking ketoprofen with an anticoagulant should be closely monitored by their doctor.

Ketoprofen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking ketoprofen with any of these should be closely monitored by their doctor:

- lithium
- methotrexate.

There may be an increased risk of side effects on the kidneys if ketoprofen is taken with any of the following medicines:

- ACE inhibitors, eg enalapril
- ciclosporin
- diuretics, eg furosemide
- tacrolimus.

Ketoprofen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:

- ACE inhibitors such as captopril
- beta-blockers such as propranolol
- diuretics such as furosemide.

Probenecid may increase the blood level of ketoprofen, which may increase the risk of side effects.

Other medicines containing the same active ingredient

Ketocid	Ketovail	Orudis
Oruvail gel	Powergel	Tiloket
Tiloket gel

Ketoprofen capsules, modified release capsules and gel are also available without a brand name, ie as the generic medicine.

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