Orudis

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Ketoprofen should not be taken in combination with painkilling doses of aspirin or any other oral NSAID, eg ibuprofen, as this increases the risk of side effects on the stomach and intestines. Selective inhibitors of COX-2 such as celecoxib or etoricoxib should also be avoided for the same reason.

There may be an increased risk of ulceration or bleeding from the gut if ketoprofen is taken with corticosteroids such as prednisolone.

There may also be an increased risk of bleeding from the gut if ketoprofen is taken with the following medicines:

anti-blood-clotting (anticoagulant) medicines such as warfarin

anti-platelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, clopidogrel, dipyridamole

SSRI antidepressants, eg fluoxetine, paroxetine, citalopram

venlafaxine.

Ketoprofen may enhance the effect of blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. As this may increase the risk of bleeding, people taking ketoprofen with an anticoagulant should be closely monitored by their doctor.

Ketoprofen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking ketoprofen with any of these should be closely monitored by their doctor:

lithium

methotrexate.

There may be an increased risk of side effects on the kidneys if ketoprofen is taken with any of the following medicines:

ACE inhibitors, eg enalapril

ciclosporin

diuretics, eg furosemide

tacrolimus.

Ketoprofen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:

ACE inhibitors such as captopril

beta-blockers such as propranolol

diuretics such as furosemide.

Probenecid may increase the blood level of ketoprofen, which may increase the risk of side effects.

Other medicines containing the same active ingredient

Ketocid	Ketovail	Oruvail
Oruvail gel	Powergel	Tiloket
Tiloket gel

Ketoprofen capsules, modified release capsules and gel are also available without a brand name, ie as the generic medicine.

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