Navoban (5mg)

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How does it work?

Tropisetron is a medicine known as a 5-HT3 receptor blocker. Serotonin (5-HT) is a chemical produced by the nervous system. Specific receptors in the body bind with serotonin with different results. 5-HT3 receptors are present in the brain and gut. Stimulation of these receptors by serotonin contributes to the sensation of nausea and the reflex action of vomiting. Tropisetron acts directly on 5-HT3 receptors in the gut to block serotonin thereby preventing nausea and vomiting. It is also thought to block 5-HT3 receptors in the brain, further preventing nausea and vomiting. Tropisetron is highly effective in the prevention of chemotherapy-induced nausea and vomiting. It may be given as capsules or injection and is given as a single dose daily for six days starting on the first day chemotherapy is received.

What is it used for?

- Prevention of chemotherapy-induced nausea and vomiting

Warning!

- This medicine may cause fatigue and dizziness. You should take care when performing potentially hazardous activites, such as driving or operating machinery, until you know how this medicine affects you and are sure you can perform such activities safely.

Use with caution in

- Disturbed heart rhythm or nerve conduction within the heart
- People taking and anti-arrhythmia or beta-blocking medicines
- Uncontrolled high blood pressure

Not to be used in

- Children
- Pregnancy

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- The manufacturer states not to use this medicine during pregnancy and breastfeeding as there is insufficient safety information available. Seek medical advice from your doctor.

Label warnings

- Take this medication an hour before food or on an empty stomach.

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