Maxolon high dose (metoclopramide)

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to ensure that the combination is safe.

Due to its action on the gut, metoclopramide may affect the absorption of various other medicines that are taken by mouth. For example, metoclopramide speeds the absorption of painkillers such as paracetamol and aspirin from the gut.

The following medicines may oppose the effect of metoclopramide on the gut:

antimuscarinic medicines, eg atropine, hyoscine, procyclidine

opioid painkillers, eg morphine, codeine.

Metoclopramide may decrease the blood level of atovaquone.

Metoclopramide may increase the blood level of ciclosporin.

Metoclopramide may increase the drowsiness and sedation that are side effects of opioid painkillers such as morphine.

There may be an increased risk of side effects known as extrapyramidal effects if metoclopramide is used with tetrabenazine or with antipsychotic medicines, eg chlorpromazine. Extrapyramidal side effects involve abnormal movements of the hands, legs, face and tongue, for example tremor or twitching.

Metoclopramide may oppose the effect of medicines for Parkinson's disease that work by stimulating dopamine receptors in the brain, for example ropinirole, pergolide, bromocriptine.

There may be an increased risk of a side effect called the serotonin syndrome if this medicine is used in combination with the following medicines:

selective serotonin reuptake inhibitor antidepressants (SSRIs), such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline

the herbal remedy St John's wort (Hypericum perforatum)

triptans for migraine, eg sumatriptan

tryptophan.

Other medicines containing the same active ingredient

Maxolon injection	Maxolon paediatric liquid	Maxolon SR
Maxolon tablets/syrup

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