Manerix (moclobemide)

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Disturbed sleep
- Dizziness
- Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
- Headache
- Anxiety and restlessness
- Agitation
- Pins and needles (paraesthesia)
- Dry mouth
- Visual disturbances
- Excessive fluid retention in the body tissues, resulting in swelling (oedema)
- Skin reactions such as rash and itch
- Confusion

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Moclobemide should not be taken at the same time as monoamine oxidase inhibitor antidepressants (MAOIs, eg phenelzine), tricyclic antidepressants (TCAs, eg amitriptyline), selective serotonin re-uptake inhibitor antidepressants (SSRIs, eg paroxetine, fluoxetine) or serotonin noradrenaline reuptake inhibitors (SNRIs, eg venlafaxine, duloxetine). Moclobemide should not be started until approximately one or two weeks (depending on the antidepressant, five weeks for fluoxetine) after these antidepressants have been stopped.

Side effects may be more common if this medicine is used in combination with the herbal remedy for depression St John's wort (Hypericum perforatum). This combination is not recommended.

People who are taking moclobemide should not take any of the following drugs, as the combination could cause a dangerous increase in blood pressure or other serious side effects:

- amphetamines
- decongestants such as ephedrine, pseudoephedrine and phenylephrine (these are found in many non-prescription cough, cold and flu remedies)
- dextromethorphan (a non-prescription cough medicine)
- ecstasy (MDMA)
- methylphenidate
- pethidine
- selegiline.

The amount of moclobemide in the blood may be increased by cimetidine. Your doctor may need to decrease your moclobemide dose if you start taking cimetidine.

There may be an increased risk of a rare side effect called the serotonin syndrome if moclobemide is taken with any of the following medicines, which also enhance the activity of serotonin in the central nervous system:

- sibutramine (not recommended for use in combination with antidepressants)
- tramadol
- triptans for migraine, eg sumatriptan
- tryptophan.

Other medicines containing the same active ingredient

Moclobemide tablets are also available without a brand name, ie as the generic medicine.

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