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Lopid

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Health Centres - Lopid



How does it work?

This medicine contains the active ingredient gemfibrozil, which is a type of medicine known as a fibrate. It works by reducing the production of fats (lipids) by the liver. These lipids include cholesterol and triglycerides. Cholesterol is one of the body's fats (lipids). Cholesterol and triglycerides are important building blocks in the structure of cells and are also used in making hormones and producing energy. To some extent, the cholesterol level in blood depends on what you eat but it is mainly dependent on how the body makes cholesterol in the liver. Having too much cholesterol in the blood is not a disease in itself, but can lead to the hardening and narrowing of the arteries (atherosclerosis). For the sake of simplicity, there are two sorts of cholesterol; a 'bad' sort called low density lipoprotein (LDL) and a 'good' sort called high density lipoprotein (HDL). LDL is deposited in the arteries and increases the risk of heart disease, while HDL actually protects the arteries against this. Triglycerides can also be considered as 'bad' fats; they also contribute to the risk of heart disease. Gemfibrozil increases the breakdown of triglycerides already present in the body. It also decreases the production of triglycerides by the liver. This lowers triglyceride levels. Gemfibrozil lowers LDL cholesterol by increasing the amount which is expelled from the gall bladder in the bile. In addition, it increases the levels of HDL cholesterol. The overall result of this is lowered levels of "bad fats" and raised levels of "good fats". Fibrates have an important role in the prevention of heart disease. They reduce the risk of fats being deposited in the major blood vessels of the heart. Any blockage in the blood vessels limits the amount of blood and therefore oxygen being carried to the heart muscle. In severe cases this can result in a heart attack (myocardial infarction). This medicine is only used when blood lipid levels cannot be lowered by diet and exercise alone. It is important to follow a diet and exercise regime when taking gemfibrozil.

What is it used for?

- High levels of fats
- Prevention of coronary heart disease in men aged 40-55 with hyperlipidaemia that has not responded to diet or other measures

Warning!

- This medicine may very rarely have side effects on the muscles. For this reason you should inform your doctor immediately if you experience any muscular symptoms such as pain, tenderness, cramps, or weakness while taking this medicine, particularly if it is accompanied by a fever or feeling generally unwell. Your doctor may need to check for side effects on the muscles by taking a blood test to measure the level of a compound called creatinine kinase in your blood. If this is the case, the test should not be done following strenuous exercise.
- This medicine is not recommended for use in children.
- You should should continue eating a cholesterol-lowering diet during treatment with this medicine. Discuss this with your doctor.
- If your doctor considers that an adequate response has not been achieved within three months of treatment with this medicine, your doctor may ask you to stop taking this medicine.
- Blood tests to monitor liver function and levels of blood components should be performed before starting treatment with this medicine, and regularly for the first year of treatment.
- Blood lipid levels should be monitored before starting and regularly throughout treatment.
- Consult your doctor if you experience troublesome pain in the upper part of your stomach, or yellowing of the skin (jaundice) while taking this medicine.

Use with caution in

- Decreased kidney function
- Diabetes
- History of liver disease
- Hypothyroidism
- Individuals who consume large quantities of alcohol
- Kidney disease

Not to be used in

- Alcoholism
- Breastfeeding
- Decreased liver function
- Gall stones
- Pregnancy

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- The safety of this medicine during pregnancy has not been established, therefore it should not be used by pregnant women. Consult your doctor.
- There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Headache
- Rash
- Itching (pruritus)
- Blurred vision
- Excess gas in the stomach and intestines (flatulence)
- Impotence
- Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
- Inflammation of the pancreas (pancreatitis)
- Abnormal reaction of the skin to light, usually a rash (photosensitivity)
- Yellowing of the skin and eyes (jaundice)
- Severe swelling of lips, face or tongue (angioedema)
- Dizziness
- Rapid and irregular beating of the heart (atrial fibrillation)
- Muscle breakdown (rhabdomyolysis)
- Muscle pain (myalgia) and weakness (myasthenia)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.



The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Conditions for use Powered by netdoctor
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