Lederfen

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Disturbances of the gut such as indigestion, diarrhoea, constipation, nausea, vomiting or abdominal pain

Rash

Headache

Dizziness

Difficulty sleeping (insomnia)

Sensation of ringing, or other noise in the ears (tinnitus)

Balance disorders involving the inner ear (vertigo)

Visual disturbances

Ulceration of the stomach or intestines

Bleeding from the stomach or intestines

Retention of water in the body tissues (fluid retention), resulting in swelling (oedema)

Abnormal reaction of the skin to light, usually a rash (photosensitivity)

Hypersensitivity reactions such as narrowing of the airways (bronchospasm), swelling of the lips, throat and tongue (angioedema) or severe skin reaction (toxic epidermal necrolysis)

Kidney, liver or blood disorders

Lung disorders

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Fenbufen should not be taken in combination with painkilling doses of aspirin or any other NSAID taken by mouth, eg ibuprofen, as this increases the risk of side effects on the stomach and intestines. Selective inhibitors of COX-2 such as celecoxib or etoricoxib should also be avoided for the same reason.

There may be an increased risk of ulceration or bleeding from the gut if fenbufen is taken with corticosteroids such as prednisolone.

There may also be an increased risk of bleeding from the gut if fenbufen is taken with the following medicines:

anti-blood-clotting (anticoagulant) medicines such as warfarin

anti-platelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, clopidogrel, dipyridamole

SSRI antidepressants, eg fluoxetine, paroxetine, citalopram

venlafaxine.

Fenbufen may enhance the effect of blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. As this may increase the risk of bleeding, people stabilised on anticoagulants such as warfarin should have their blood clotting time (INR) monitored if fenbufen is added to treatment.

Fenbufen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking fenbufen with any of these should be closely monitored by their doctor:

digoxin

lithium

methotrexate.

There may be an increased risk of side effects on the kidneys if fenbufen is taken with any of the following medicines:

ACE inhibitors, eg enalapril

ciclosporin

diuretics, eg furosemide

tacrolimus.

Fenbufen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:

ACE inhibitors such as captopril

beta-blockers such as atenolol

diuretics such as furosemide.

Quinolone antibiotics, such as enoxacin, ofloxacin or ciprofloxacin, should be avoided in people taking fenbufen, as the combination may increase the risk of seizures (convulsions).

Other medicines containing the same active ingredient

Fenbufen capsules and tablets are available without a brand name, ie as the generic medicine.

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