Lasilactone

How can this medicine affect other medicines?

When taken together with ACE inhibitors or potassium salts there is an increased risk of high blood potassium levels (hyperkalaemia). This combination should be avoided. Spironolactone increases the levels of cardiac glycosides such as digoxin in the blood. Furosemide causes a loss of potassium (hypokalaemia) from the blood, which may increase the risk of adverse effects when taken with cardiac glycosides such as digoxin. Spironolactone decreases the ulcer healing effects of carbenoxolone. Corticosteroids such as hydrocortisone may also cause potassium loss and severe depletion may occur if they are used with furosemide. When taken together with medicines that decrease blood pressure there is an increased risk of a large drop in blood pressure and fainting, especially when given with the first dose of ACE inhibitors (eg captopril). The blood pressure lowering and diuretic effects of furosemide may be reduced or abolished when used together with indomethacin and possibly other non-steroidal anti-inflammatory (NSAIDs) medicines . Furosemide may reduce the ability of the body to remove lithium, leading to increased amounts of lithium in the blood. This may give rise to increased adverse effects.

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