Ketocid

How does it work?

Ketocid modified release capsules contain the active ingredient ketoprofen, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are used to relieve pain and inflammation. (NB. Ketoprofen is also available without a brand name, ie as the generic medicine.)

Ketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced by the body in response to injury and certain diseases and conditions, and cause pain, swelling and inflammation. Ketoprofen blocks the production of these prostaglandins and is therefore effective at reducing inflammation and pain.

Ketoprofen is used to relieve pain and inflammation in a wide range of musculoskeletal conditions, including various forms of arthritis, gout, muscle sprains and strains, back pain, neck pain and tendinitis. It can also be used to relieve period pain.

Ketocid modified release capsules are designed to release the ketoprofen slowly and continuously over several hours. This provides prolonged pain relief, so these capsules are taken once a day. The capsules must be swallowed whole to avoid damaging the modified release action.

Ketocid modified release capsules should preferably be taken with food to help avoid irritating the stomach.

What is it used for?

In adults, relief of pain and inflammation in a wide range of conditions, including the following:

Rheumatoid arthritis

Osteoarthritis

A form of arthritis affecting the joints of the spine (ankylosing spondylitis)

Acute gout

Acute inflammatory disorders of the joints, such as tendon inflammation (tendinitis), bursitis, capsulitis, synovitis

Painful disorders of the muscles and skeleton, such as sprains, strains, fibrositis, dislocations, fractures

Neck pain due to inflammation of the vertebrae in the neck (cervical spondylitis)

Lower back pain

Pain that travels from the back into the buttock and back of leg (sciatica)

Pain and inflammation following orthopaedic (bone) surgery

Painful periods

Warning!

Ketocid capsules should be swallowed whole with water and not broken, chewed or crushed. They should be taken with or after food to help avoid irritating the stomach.

NSAIDs can occasionally cause serious side effects on the gut, such as ulceration, bleeding or perforation of the stomach or intestinal lining. This type of side effect is more likely to occur in elderly people and in people taking high doses of the medicine. The risk can also be increased by taking certain other medicines (see below). It is important that these people, as well as people with a history of disorders affecting the stomach or intestines, are closely monitored by a doctor while taking this medicine. If your doctor thinks you are at high risk of side effects on the gut you may be prescribed an additional medicine to help protect your gut. All people taking this medicine should stop treatment and consult their doctor immediately if they experience any sign of bleeding from the stomach or intestine during treatment, for example vomiting blood and/or passing black/tarry/bloodstained stools.

This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.

If you have cirrhosis of the liver, heart failure or kidney disease, you are taking diuretic medicines, or you are recovering from major surgery, your kidney function should be assessed before starting and regularly throughout treatment with this medicine.

During long-term treatment with this medicine you should have regular check-ups with your doctor so that you can be monitored for possible side effects of the medicine. This might include routine blood tests to monitor your kidney function, liver function and levels of blood components, particularly if you are elderly.

Very rarely, NSAIDS may cause serious blistering or peeling skin reactions (eg Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis). For this reason, you should stop taking this medicine and consult your doctor if you get a skin rash or sores inside your mouth while taking this medicine. This side effect is very rare, but if it occurs, is most likely to happen in the first month of treatment.

Use with caution in

Elderly people

History of disorders affecting the stomach or intestines

Inflammatory bowel disease such as Crohn's disease or ulcerative colitis

Decreased kidney function

Decreased liver function

Heart failure

High blood pressure

History of asthma

History of allergies

People with blood clotting disorders or taking anticoagulants

Not to be used in

Children

People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema)

Active peptic ulcer or bleeding from the gut

People who have had recurrent peptic ulcers or bleeding from the gut (two or more episodes)

People who have experienced bleeding or perforation of the gut as a result of previous treatment with an NSAID

Severely decreased kidney function

Severe heart failure.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine is not recommended for use in pregnancy unless considered essential by your doctor. This is particularly important in the first and third trimesters. If taken in the third trimester it may delay labour, increase the length of labour and cause complications in the newborn baby. Some evidence suggests that NSAIDs should also be avoided by women attempting to conceive, as they may temporarily reduce female fertility during treatment and may also increase the risk of miscarriage or malformations. Seek medical advice from your doctor.

This medicine may pass into breast milk, but in such small quantities that it is unlikely to harm the baby. However, the manufacturer recommends that this medicine is avoided by women who are breastfeeding, unless it is considered essential by your doctor. Seek medical advice from your doctor.

Label warnings

Take this medication with or after food.

This medication is to be swallowed whole, not chewed.

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