Isoniazid

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Allergy to active ingredients (hypersensitivity)
- Seizures (convulsions)
- Loss of contact with reality (psychosis)
- Nausea and vomiting
- Inflammation of the liver (hepatitis)
- "Pins and needles" sensation in hands and feet (peripheral neuritis)
- Sudden severe deficiency in the number of white blood cells in the blood (agranulocytosis)
- Inflammation of the optic nerve (the nerve connecting the eye to the brain) which results in blurring of vision (optic neuritis)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

The effect of carbamazepine, ethosuxamide and phenytoin is increased when isoniazid is taken at the same time because the isoniazid inhibits their metabolism by the liver. The level of ketoconazole in the blood may be reduced by isoniazid. Isoniazid increases the risk of liver damage when taken with carbamazapine. The combination of cycloserine and isoniazid increases the risk of toxicity to the central nervous system and patients on these two anti-TB drugs should be monitored closely. Isoniazid may increase the level of theophylline in the blood. Isoniazid increases the risk of liver damage if used with the anaesthetic isoflurane.

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